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README.md 597 B

CR_Project

Code and project management repository for Castration/Regeneration multiome analysis (Estelle Deby @KathausLab EPFL)

2-step strategy for TF discovery

  1. Identify regions that show differential accessibility between Castrate Day 28 (CD28) and Intact samples, filtering them based on absolute fold change (-FoldChanges for less accessible in CD28, +FoldCchanges for more accessible) in CD28 and adjusted p-value.

  2. Test these regions for TF binding motif enrichment, looking for top hits using the delta FoldChange of the TF enrichment (more accessible - less accessible).